{tab=Research}Thomas Moritz in front of a mass spectrometer

The aim of my research is to understand the mechanisms of metabolic control of shoot elongation and wood formation in the model plant Populus. We want to understand how plant hormones and other metabolites are involved in the control of plant development, and how different environmental cues, such as photoperiod, affect the metabolic control of growth and development. The metabolic control of growth and development are studied by using both targeted and untargeted metabolomics approaches.

Gibberellins (GAs) are a group of tetracyclic diterpenes, some of which are essential endogenous regulators that influence growth and development events throughout the life cycle of a plant, e.g. shoot elongation, expansion and shape of leaves, flowering and seed germination. Our project is concerned with the role of GAs in plant development, and daylength responses, focusing on the tree hybrid aspen (Populus tremula x P. tremuloides) as a model system. Our approach for studying the role of GAs in trees is to study endogenous expression of GA biosynthetic and signalling genes and to transform Populus with genes encoding those genes.

Populus transformed with the AtGA20ox1 under the control of the 35S promoter shows elongated internodes, longer petioles and larger leaves, reduced root formation and increased shoot biomass.We have also char- acterized the GA receptor, GID1 in Populus. Four orthologs of GID1 have been identified in Populus tremula x P. tremuloides (PttGID1.1 to 1.4). When PttGID1.1 and PttGID1.3 were overexpressed in Populus with a 35S promoter, overexpressors shared several similar phenotypic traits with previously described 35S:AtGA20ox1 overexpressors, including rapid growth and increased elongation.

Three photos showing parts of a mass spectrometer instrument that is used to measure metabolites

We are also studying the role of GAs and other signaling compounds in wood formation. The role of GAs is done by both using transgenic Populus with increased levels of GAs and signalling and by predicting where GAs are formed and perceived during wood formation. For example, we have quantified GAs and analyzed the expression of GA biosynthesis genes and genes with predicted roles in GA signalling in tangential sections across the cambial region of aspen trees (Populus tremula). The results show, for example inter alia, that the bioactive GA and GA 14 predominantly occur in the zone of expansion of xylem cells.

Studies with transgenic Populus overexpressing AtGA20ox1 or PttGID1 with 35S or a xylem-specific promoter, suggest that GAs are required for two distinct processes in wood formation with tissue-specific signalling pathways: xylogenesis, mediated by GA signalling in the cambium, and fibre elongation in developing xylem.

By using a metabolomics approach we are also studying how specific patterns of metabolites, including signalling compounds, are vary in different regions of the wood-forming zone in Populus. From the data we can conclude that cambial activity, cell expansion and secondary cell wall thickening are tightly coupled processes, Many of these patterns can be explained on the basis of the developmental processes taking place within these regions, e.g. in the cambium.

Many woody species with indeterminate growth show complete cessation of elongation growth after only a few weeks in short photoperiods. In hybrid aspen transformed with the oat PHYA gene, the dwarf phenotype is correlated with a reduction in GA levels, but in short photoperiods there is no further reduction in GA contents, in marked contrast to the pattern in wild-type plants. These observations imply that GAs have an important role as signals in the photoperiodic regulation of shoot elongation. We have also been studying transgenic GA plants to elucidate how changes in GA levels and signalling affect photoperiodic growth. Studies in PHYA and GA biosynthesis/signalling overexpressors are used with transcriptomic and metabolomic approaches to elucidate the early signalling pathways in short-day induced growth cessation, including identification of new putative signalling compounds.

Key Publications

  • Davoine, C., Abreu, I. N. Khajeh, K., Blomberg, J., Kidd, B. N., Kazan, K., Schenk, P. M., Gerber, L., Nilsson, O., Moritz, T. , Bjorklund, S. 2017. Functional metabolomics as a tool to analyze mediator function and structure in plants. Plos One 12(6).
  • Lindén, P., Keech, O., Stenlund, H., Gardeström, P., Moritz, T. 2016 Reduced mitochondrial malate dehydrogenase activity has a strong effect on photorespiratory metabolism as revealed by 13C-labelling. J. Exp. Bot., 67: 3123-3135
  • Eriksson, M.E., Hoffman, D., Kaduk, M., Mauriat, M., Moritz, T. 2015 Transgenic hybrid aspen trees with increased gibberellin (GA) concentrations suggest that GA acts in parallel with FLOWERING LOCUS T2 to control shoot elongation. New Phytologist, 205, 1288-1295.
  • Mauriat M., Sandberg L., Moritz T. 2011 Proper gibberellin localization in vascular tissue is required to control auxin dependent leaf development and bud outgrowth in hybrid aspen. Plant J. 67: 805-816.
  • Mauriat M., Moritz T. 2009 Analyses of GA20ox- and GID1-overexpressing Populus suggest gibberellins play two distinct roles in wood formation. Plant J. 58: 989-1003.
  • Israelsson M., Sundberg B., Moritz T. 2005 Tissue-specific localisation of gibberellins in wood-forming tissues in aspen. Plant J. 44: 494-504.
  • Jonsson P., Johansson A., Gullberg J., Trygg J., A J., Grung B., Marklund S., Sjöström M., Antti H., Moritz T. 2005 High through-put data analysis for detecting and identifying differences between samples in GC/MS-based metabolomic analyses Anal. Chem. 77: 5635-5642.
  • Eriksson M., Israelsson M., Olsson O., Moritz T. 2000. Increased gibberellin biosynthesis in transgenic trees promotes growth, biomass production and xylem fibre length. Nature Biotech. 784-788.
{tab=Team}
  • Personnel Image
    Ahnlund, Maria
    Research Engineer
    E-mail
    Room: B6-52-45
  • Personnel Image
    Hodek, Ondřej
    PostDoc
    E-mail
    Room: B6-52-45
  • Personnel Image
    Moritz, Thomas
    Professor
    E-mail
    Room:
    Website
  • Personnel Image
    Näsström, Elin
    Research Engineer
    E-mail
    Room: B6-48-45
  • Personnel Image
    Pettersson, Cecilia
    Research Engineer
    E-mail
    Room: B6-52-45
  • Personnel Image
    Stenlund, Hans
    Staff scientist
    E-mail
    Room: B6-48-45

{tab=CV T. Moritz}
  • Since 2019: Professor, University of Copenhagen (80%); Swedish University of Agricultural Sciences (20%)
  • 2013-2019: Director Swedish Metabolomics Centre
  • 2007-2015: Head of Department (Dept. Forest Genetics and Plant Physiology)
  • 2002: Professor, Swedish University of Agricultural Sciences
  • 1997: Docent, Swedish University of Agricultural Sciences
  • 1992: Assistant Professor, Swedish University of Agricultural Sciences
  • 1991: Postdoc, Long Ashton Research Station, Bristol, UK
  • 1990: PhD, Swedish University of Agricultural Sciences
  • 1985: BSc, Umeå University
{tab=Publications}
  2024 (1)
Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health. Lecoutre, S., Maqdasy, S., Rizo-Roca, D., Renzi, G., Vlassakev, I., Alaeddine, L. M., Higos, R., Jalkanen, J., Zhong, J., Zareifi, D. S., Frendo-Cumbo, S., Massier, L., Hodek, O., Juvany, M., Moritz, T., de Castro Barbosa, T., Omar-Hmeadi, M., López-Yus, M., Merabtene, F., Abatan, J. B., Marcelin, G., El Hachem, E., Rouault, C., Bergo, M. O., Petrus, P., Zierath, J. R., Clément, K., Krook, A., Mejhert, N., & Rydén, M. Nature Metabolism, 6(7): 1329–1346. July 2024. Publisher: Nature Publishing Group
Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health [link]Paper   doi   link   bibtex   abstract  
  2023 (3)
Oak stands along an elevation gradient have different molecular strategies for regulating bud phenology. Le Provost, G., Lalanne, C., Lesur, I., Louvet, J., Delzon, S., Kremer, A., Labadie, K., Aury, J., Da Silva, C., Moritz, T., & Plomion, C. BMC Plant Biology, 23(1): 108. February 2023.
Oak stands along an elevation gradient have different molecular strategies for regulating bud phenology [link]Paper   doi   link   bibtex   abstract  
Structural elucidation of 3-nitrophenylhydrazine derivatives of tricarboxylic acid cycle acids and optimization of their fragmentation to boost sensitivity in liquid chromatography-mass spectrometry. Hodek, O., Henderson, J., Argemi-Muntadas, L., Khan, A., & Moritz, T. Journal of Chromatography B, 1222: 123719. April 2023.
Structural elucidation of 3-nitrophenylhydrazine derivatives of tricarboxylic acid cycle acids and optimization of their fragmentation to boost sensitivity in liquid chromatography-mass spectrometry [link]Paper   doi   link   bibtex   abstract  
Xylan glucuronic acid side chains fix suberin-like aliphatic compounds to wood cell walls. Derba-Maceluch, M., Mitra, M., Hedenström, M., Liu, X., Gandla, M. L., Barbut, F. R., Abreu, I. N., Donev, E. N., Urbancsok, J., Moritz, T., Jönsson, L. J., Tsang, A., Powlowski, J., Master, E. R., & Mellerowicz, E. J. New Phytologist, 238(1): 297–312. January 2023. _eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1111/nph.18712
Xylan glucuronic acid side chains fix suberin-like aliphatic compounds to wood cell walls [link]Paper   doi   link   bibtex   abstract  
  2022 (7)
Circum-Arctic distribution of chemical anti-herbivore compounds suggests biome-wide trade-off in defence strategies in Arctic shrubs. Lindén, E., te Beest, M., Aubreu, I., Moritz, T., Sundqvist, M. K., Barrio, I. C., Boike, J., Bryant, J. P., Bråthen, K. A., Buchwal, A., Bueno, C. G., Currier, A., Egelkraut, D. D., Forbes, B. C., Hallinger, M., Heijmans, M., Hermanutz, L., Hik, D. S., Hofgaard, A., Holmgren, M., Huebner, D. C., Høye, T. T., Jónsdóttir, I. S., Kaarlejärvi, E., Kissler, E., Kumpula, T., Limpens, J., Myers-Smith, I. H., Normand, S., Post, E., Rocha, A. V., Schmidt, N. M., Skarin, A., Soininen, E. M., Sokolov, A., Sokolova, N., Speed, J. D. M., Street, L., Tananaev, N., Tremblay, J., Urbanowicz, C., Watts, D. A., Zimmermann, H., & Olofsson, J. Ecography,e06166. August 2022.
Circum-Arctic distribution of chemical anti-herbivore compounds suggests biome-wide trade-off in defence strategies in Arctic shrubs [link]Paper   doi   link   bibtex   abstract  
Impaired phosphocreatine metabolism in white adipocytes promotes inflammation. Maqdasy, S., Lecoutre, S., Renzi, G., Frendo-Cumbo, S., Rizo-Roca, D., Moritz, T., Juvany, M., Hodek, O., Gao, H., Couchet, M., Witting, M., Kerr, A., Bergo, M. O., Choudhury, R. P., Aouadi, M., Zierath, J. R., Krook, A., Mejhert, N., & Rydén, M. Nature Metabolism, 4(2): 1–13. February 2022.
Impaired phosphocreatine metabolism in white adipocytes promotes inflammation [link]Paper   doi   link   bibtex   abstract  
Metabolic control of arginine and ornithine levels paces the progression of leaf senescence. Liebsch, D., Juvany, M., Li, Z., Wang, H., Ziolkowska, A., Chrobok, D., Boussardon, C., Wen, X., Law, S. R, Janečková, H., Brouwer, B., Lindén, P., Delhomme, N., Stenlund, H., Moritz, T., Gardeström, P., Guo, H., & Keech, O. Plant Physiology, 189(4): 1943–1960. August 2022.
Metabolic control of arginine and ornithine levels paces the progression of leaf senescence [link]Paper   doi   link   bibtex   abstract  
Mixed-mode chromatography-mass spectrometry enables targeted and untargeted screening of carboxylic acids in biological samples. Hodek, O., Argemi-Muntadas, L., Khan, A., & Moritz, T. Analytical Methods, 14(10): 1015–1022. January 2022.
Mixed-mode chromatography-mass spectrometry enables targeted and untargeted screening of carboxylic acids in biological samples [link]Paper   doi   link   bibtex   abstract  
Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health. Marabita, F., James, T., Karhu, A., Virtanen, H., Kettunen, K., Stenlund, H., Boulund, F., Hellström, C., Neiman, M., Mills, R., Perheentupa, T., Laivuori, H., Helkkula, P., Byrne, M., Jokinen, I., Honko, H., Kallonen, A., Ermes, M., Similä, H., Lindholm, M., Widén, E., Ripatti, S., Perälä-Heape, M., Engstrand, L., Nilsson, P., Moritz, T., Miettinen, T., Sallinen, R., & Kallioniemi, O. Cell Systems, 13(3): 241–255.e7. March 2022.
Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health [link]Paper   doi   link   bibtex  
Sucrose synthase activity is not required for cellulose biosynthesis in Arabidopsis. Wang, W., Viljamaa, S., Hodek, O., Moritz, T., & Niittylä, T. The Plant Journal, 110(5): 1493–1497. 2022.
Sucrose synthase activity is not required for cellulose biosynthesis in Arabidopsis [link]Paper   doi   link   bibtex   abstract  
The human batokine EPDR1 regulates β-cell metabolism and function. Cataldo, L. R., Gao, Q., Argemi-Muntadas, L., Hodek, O., Cowan, E., Hladkou, S., Gheibi, S., Spégel, P., Prasad, R. B., Eliasson, L., Scheele, C., Fex, M., Mulder, H., & Moritz, T. Molecular Metabolism, 66: 101629. December 2022.
The human batokine EPDR1 regulates β-cell metabolism and function [link]Paper   doi   link   bibtex   abstract  
  2021 (3)
A metabolomic study of Gomphrena agrestis in Brazilian Cerrado suggests drought-adaptive strategies on metabolism. Melo, G. A., Abreu, I. N., de Oliveira, M. B., Budzinski, I. G. F., Silva, L. V., Pimenta, M. A. S., & Moritz, T. Scientific Reports, 11(1): 12933. June 2021.
A metabolomic study of Gomphrena agrestis in Brazilian Cerrado suggests drought-adaptive strategies on metabolism [link]Paper   doi   link   bibtex   abstract   1 download  
Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes. Sjögren, R. J. O., Rizo-Roca, D., Chibalin, A. V., Chorell, E., Furrer, R., Katayama, S., Harada, J., Karlsson, H. K. R., Handschin, C., Moritz, T., Krook, A., Näslund, E., & Zierath, J. R. Diabetologia, 64(9): 2077–2091. September 2021.
Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes [link]Paper   doi   link   bibtex   abstract   1 download  
Overexpression of vesicle-associated membrane protein PttVAP27-17 as a tool to improve biomass production and the overall saccharification yields in Populus trees. Gandla, M. L., Mähler, N., Escamez, S., Skotare, T., Obudulu, O., Möller, L., Abreu, I. N., Bygdell, J., Hertzberg, M., Hvidsten, T. R., Moritz, T., Wingsle, G., Trygg, J., Tuominen, H., & Jönsson, L. J. Biotechnology for Biofuels, 14(1): 43. December 2021.
Overexpression of vesicle-associated membrane protein PttVAP27-17 as a tool to improve biomass production and the overall saccharification yields in Populus trees [link]Paper   doi   link   bibtex   abstract   6 downloads  
  2020 (5)
A metabolite roadmap of the wood‐forming tissue in Populus tremula. Abreu, I. N., Johansson, A. I., Sokołowska, K., Niittylä, T., Sundberg, B., Hvidsten, T. R., Street, N. R., & Moritz, T. New Phytologist, 228(5): 1559–1572. December 2020.
A metabolite roadmap of the wood‐forming tissue in Populus tremula [link]Paper   doi   link   bibtex   2 downloads  
Changes in lipid and carotenoid metabolism in Chlamydomonas reinhardtii during induction of CO2-concentrating mechanism: Cellular response to low CO2 stress. Abreu, I. N., Aksmann, A., Bajhaiya, A. K., Benlloch, R., Giordano, M., Pokora, W., Selstam, E., & Moritz, T. Algal Research, 52: 102099. December 2020.
Changes in lipid and carotenoid metabolism in Chlamydomonas reinhardtii during induction of CO2-concentrating mechanism: Cellular response to low CO2 stress [link]Paper   doi   link   bibtex  
Differentiation of two Maytenus species and their hybrid via untargeted metabolomics. Antunes, E. R. M., Duarte, R. S., Moritz, T., & Sawaya, A. C. H. F. Industrial Crops and Products, 158: 113014. December 2020.
Differentiation of two Maytenus species and their hybrid via untargeted metabolomics [link]Paper   doi   link   bibtex  
Integration of molecular profiles in a longitudinal wellness profiling cohort. Tebani, A., Gummesson, A., Zhong, W., Koistinen, I. S., Lakshmikanth, T., Olsson, L. M., Boulund, F., Neiman, M., Stenlund, H., Hellström, C., Karlsson, M. J., Arif, M., Dodig-Crnković, T., Mardinoglu, A., Lee, S., Zhang, C., Chen, Y., Olin, A., Mikes, J., Danielsson, H., von Feilitzen, K., Jansson, P., Angerås, O., Huss, M., Kjellqvist, S., Odeberg, J., Edfors, F., Tremaroli, V., Forsström, B., Schwenk, J. M., Nilsson, P., Moritz, T., Bäckhed, F., Engstrand, L., Brodin, P., Bergström, G., Uhlen, M., & Fagerberg, L. Nature Communications, 11(1): 4487. December 2020.
Integration of molecular profiles in a longitudinal wellness profiling cohort [link]Paper   doi   link   bibtex   abstract  
Metabolic Profiling and Compound-Class Identification Reveal Alterations in Serum Triglyceride Levels in Mice Immunized with Human Vaccine Adjuvant Alum. Khoomrung, S., Nookaew, I., Sen, P., Olafsdottir, T. A., Persson, J., Moritz, T., Andersen, P., Harandi, A. M., & Nielsen, J. Journal of Proteome Research, 19(1): 269–278. January 2020.
Metabolic Profiling and Compound-Class Identification Reveal Alterations in Serum Triglyceride Levels in Mice Immunized with Human Vaccine Adjuvant Alum [link]Paper   doi   link   bibtex  
  2019 (5)
Heterologous phosphoketolase expression redirects flux towards acetate, perturbs sugar phosphate pools and increases respiratory demand in Saccharomyces cerevisiae. Bergman, A., Hellgren, J., Moritz, T., Siewers, V., Nielsen, J., & Chen, Y. Microbial Cell Factories, 18(1): 25. December 2019.
Heterologous phosphoketolase expression redirects flux towards acetate, perturbs sugar phosphate pools and increases respiratory demand in Saccharomyces cerevisiae [link]Paper   doi   link   bibtex  
Leaf metabolic signatures induced by real and simulated herbivory in black mustard (Brassica nigra). Papazian, S., Girdwood, T., Wessels, B. A., Poelman, E. H., Dicke, M., Moritz, T., & Albrectsen, B. R. Metabolomics, 15(10): 130. October 2019.
Leaf metabolic signatures induced by real and simulated herbivory in black mustard (Brassica nigra) [link]Paper   doi   link   bibtex   abstract   2 downloads  
PECTIN ACETYLESTERASE9 Affects the Transcriptome and Metabolome and Delays Aphid Feeding. Kloth, K. J., Abreu, I. N., Delhomme, N., Petřík, I., Villard, C., Ström, C., Amini, F., Novák, O., Moritz, T., & Albrectsen, B. R. Plant Physiology, 181(4): 1704–1720. December 2019.
PECTIN ACETYLESTERASE9 Affects the Transcriptome and Metabolome and Delays Aphid Feeding [link]Paper   doi   link   bibtex  
Targeted Multiple Reaction Monitoring Analysis of CSF Identifies UCHL1 and GPNMB as Candidate Biomarkers for ALS. Zhu, S., Wuolikainen, A., Wu, J., Öhman, A., Wingsle, G., Moritz, T., Andersen, P. M., Forsgren, L., & Trupp, M. Journal of Molecular Neuroscience, 69(4): 643–657. December 2019.
Targeted Multiple Reaction Monitoring Analysis of CSF Identifies UCHL1 and GPNMB as Candidate Biomarkers for ALS [link]Paper   doi   link   bibtex   abstract  
Two-step derivatization for determination of sugar phosphates in plants by combined reversed phase chromatography/tandem mass spectrometry. Rende, U., Niittylä, T., & Moritz, T. Plant Methods, 15(1): 127. December 2019.
Two-step derivatization for determination of sugar phosphates in plants by combined reversed phase chromatography/tandem mass spectrometry [link]Paper   doi   link   bibtex   abstract  
  2018 (5)
A multi-omics approach reveals function of Secretory Carrier-Associated Membrane Proteins in wood formation of​ ​​Populus​​ ​trees. Obudulu, O., Mähler, N., Skotare, T., Bygdell, J., Abreu, I. N., Ahnlund, M., Latha Gandla, M., Petterle, A., Moritz, T., Hvidsten, T. R., Jönsson, L. J., Wingsle, G., Trygg, J., & Tuominen, H. BMC Genomics, 19(1): 11. December 2018.
A multi-omics approach reveals function of Secretory Carrier-Associated Membrane Proteins in wood formation of​ ​​Populus​​ ​trees [link]Paper   doi   link   bibtex   1 download  
Darkened Leaves Use Different Metabolic Strategies for Senescence and Survival. Law, S. R., Chrobok, D., Juvany, M., Delhomme, N., Lindén, P., Brouwer, B., Ahad, A., Moritz, T., Jansson, S., Gardeström, P., & Keech, O. Plant Physiology, 177(1): 132–150. May 2018.
Darkened Leaves Use Different Metabolic Strategies for Senescence and Survival [link]Paper   doi   link   bibtex   2 downloads  
Metabolic Profiling of Multiorgan Samples: Evaluation of MODY5/RCAD Mutant Mice. Torell, F., Bennett, K., Cereghini, S., Fabre, M., Rännar, S., Lundstedt-Enkel, K., Moritz, T., Haumaitre, C., Trygg, J., & Lundstedt, T. Journal of Proteome Research, 17(7): 2293–2306. July 2018.
Metabolic Profiling of Multiorgan Samples: Evaluation of MODY5/RCAD Mutant Mice [link]Paper   doi   link   bibtex  
Optimising methods for the recovery and quantification of di- and tripeptides in soil. Jämtgård, S., Robinson, N., Moritz, T., Colgrave, M. L., & Schmidt, S. Soil Research, 56(4): 404. 2018.
Optimising methods for the recovery and quantification of di- and tripeptides in soil [link]Paper   doi   link   bibtex   abstract  
Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry. Kong, Z., Jia, S., Chabes, A. L., Appelblad, P., Lundmark, R., Moritz, T., & Chabes, A. Nucleic Acids Research, 46(11): e66–e66. June 2018.
Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry [link]Paper   doi   link   bibtex  
  2017 (6)
At bHLH68 transcription factor contributes to the regulation of ABA homeostasis and drought stress tolerance in Arabidopsis thaliana. Le Hir, R., Castelain, M., Chakraborti, D., Moritz, T., Dinant, S., & Bellini, C. Physiologia Plantarum, 160(3): 312–327. July 2017.
At <i>bHLH68</i> transcription factor contributes to the regulation of ABA homeostasis and drought stress tolerance in <i>Arabidopsis thaliana</i> [link]Paper   doi   link   bibtex  
Defense Responses in Aspen with Altered Pectin Methylesterase Activity Reveal the Hormonal Inducers of Tyloses. Leśniewska, J., Öhman, D., Krzesłowska, M., Kushwah, S., Barciszewska-Pacak, M., Kleczkowski, L. A., Sundberg, B., Moritz, T., & Mellerowicz, E. J. Plant Physiology, 173(2): 1409–1419. February 2017.
Defense Responses in Aspen with Altered Pectin Methylesterase Activity Reveal the Hormonal Inducers of Tyloses [link]Paper   doi   link   bibtex   1 download  
Enhanced Secondary- and Hormone Metabolism in Leaves of Arbuscular Mycorrhizal Medicago truncatula. Adolfsson, L., Nziengui, H., Abreu, I. N, Šimura, J., Beebo, A., Herdean, A., Aboalizadeh, J., Široká, J., Moritz, T., Novák, O., Ljung, K., Schoefs, B., & Spetea, C. Plant Physiology, 175(1): 392–411. September 2017.
Enhanced Secondary- and Hormone Metabolism in Leaves of Arbuscular Mycorrhizal <i>Medicago truncatula</i> [link]Paper   doi   link   bibtex  
Functional metabolomics as a tool to analyze Mediator function and structure in plants. Davoine, C., Abreu, I. N., Khajeh, K., Blomberg, J., Kidd, B. N., Kazan, K., Schenk, P. M., Gerber, L., Nilsson, O., Moritz, T., & Björklund, S. PLOS ONE, 12(6): e0179640. June 2017.
Functional metabolomics as a tool to analyze Mediator function and structure in plants [link]Paper   doi   link   bibtex  
Metabolome and transcriptome profiling reveal new insights into somatic embryo germination in Norway spruce (Picea abies). Dobrowolska, I., Businge, E., Abreu, I. N, Moritz, T., & Egertsdotter, U. Tree Physiology, 37(12): 1752–1766. December 2017.
Metabolome and transcriptome profiling reveal new insights into somatic embryo germination in Norway spruce (Picea abies) [link]Paper   doi   link   bibtex  
Nitrogen uptake and assimilation in proliferating embryogenic cultures of Norway spruce—Investigating the specific role of glutamine. Carlsson, J., Svennerstam, H., Moritz, T., Egertsdotter, U., & Ganeteg, U. PLOS ONE, 12(8): e0181785. August 2017.
Nitrogen uptake and assimilation in proliferating embryogenic cultures of Norway spruce—Investigating the specific role of glutamine [link]Paper   doi   link   bibtex  
  2016 (8)
Central Metabolic Responses to Ozone and Herbivory Affect Photosynthesis and Stomatal Closure. Papazian, S., Khaling, E., Bonnet, C., Lassueur, S., Reymond, P., Moritz, T., Blande, J. D., & Albrectsen, B. R. Plant Physiology, 172(3): 2057–2078. November 2016.
Central Metabolic Responses to Ozone and Herbivory Affect Photosynthesis and Stomatal Closure [link]Paper   doi   link   bibtex   2 downloads  
Dissecting the Metabolic Role of Mitochondria during Developmental Leaf Senescence. Chrobok, D., Law, S. R., Brouwer, B., Lindén, P., Ziolkowska, A., Liebsch, D., Narsai, R., Szal, B., Moritz, T., Rouhier, N., Whelan, J., Gardeström, P., & Keech, O. Plant Physiology, 172(4): 2132–2153. December 2016.
Dissecting the Metabolic Role of Mitochondria during Developmental Leaf Senescence [link]Paper   doi   link   bibtex  
Integrated analysis of gene expression from carbon metabolism, proteome and metabolome, reveals altered primary metabolism in Eucalyptus grandis bark, in response to seasonal variation. Budzinski, I. G. F., Moon, D. H., Morosini, J. S., Lindén, P., Bragatto, J., Moritz, T., & Labate, C. A. BMC Plant Biology, 16(1): 149. December 2016.
Integrated analysis of gene expression from carbon metabolism, proteome and metabolome, reveals altered primary metabolism in Eucalyptus grandis bark, in response to seasonal variation [link]Paper   doi   link   bibtex  
Metabolomic Quality Assessment of EDTA Plasma and Serum Samples. Malm, L., Tybring, G., Moritz, T., Landin, B., & Galli, J. Biopreservation and Biobanking, 14(5): 416–423. October 2016.
Metabolomic Quality Assessment of EDTA Plasma and Serum Samples [link]Paper   doi   link   bibtex  
Multi-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects. Wuolikainen, A., Jonsson, P., Ahnlund, M., Antti, H., Marklund, S. L., Moritz, T., Forsgren, L., Andersen, P. M., & Trupp, M. Molecular BioSystems, 12(4): 1287–1298. 2016.
Multi-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects [link]Paper   doi   link   bibtex   abstract  
Quantitative proteomics reveals protein profiles underlying major transitions in aspen wood development. Obudulu, O., Bygdell, J., Sundberg, B., Moritz, T., Hvidsten, T. R., Trygg, J., & Wingsle, G. BMC Genomics, 17(1): 119. December 2016.
Quantitative proteomics reveals protein profiles underlying major transitions in aspen wood development [link]Paper   doi   link   bibtex  
Reduced mitochondrial malate dehydrogenase activity has a strong effect on photorespiratory metabolism as revealed by $^{\textrm{13}}$ C labelling. Lindén, P., Keech, O., Stenlund, H., Gardeström, P., & Moritz, T. Journal of Experimental Botany, 67(10): 3123–3135. May 2016.
Reduced mitochondrial malate dehydrogenase activity has a strong effect on photorespiratory metabolism as revealed by $^{\textrm{13}}$ C labelling [link]Paper   doi   link   bibtex  
Seasonal Variation of Carbon Metabolism in the Cambial Zone of Eucalyptus grandis. Budzinski, I. G. F., Moon, D. H., Lindén, P., Moritz, T., & Labate, C. A. Frontiers in Plant Science, 7. June 2016.
Seasonal Variation of Carbon Metabolism in the Cambial Zone of Eucalyptus grandis [link]Paper   doi   link   bibtex  
  2015 (4)
13C Tracking after 13CO2 Supply Revealed Diurnal Patterns of Wood Formation in Aspen. Mahboubi, A., Linden, P., Hedenstrom, M., Moritz, T., & Niittylä, T. Plant Physiol, 168(2): 478–89. June 2015.
13C Tracking after 13CO2 Supply Revealed Diurnal Patterns of Wood Formation in Aspen [link]Paper   doi   link   bibtex   abstract  
Cell-type specific metabolic profiling of Arabidopsis thaliana protoplasts as a tool for plant systems biology. Petersson, S. V., Linden, P., Moritz, T., & Ljung, K. Metabolomics, 11(6): 1679–1689. December 2015. Edition: 2015/10/23
Cell-type specific metabolic profiling of Arabidopsis thaliana protoplasts as a tool for plant systems biology [link]Paper   doi   link   bibtex   abstract  
Silencing C19-GA 2-oxidases induces parthenocarpic development and inhibits lateral branching in tomato plants. Martinez-Bello, L., Moritz, T., & Lopez-Diaz, I. J Exp Bot, 66(19): 5897–910. September 2015. Edition: 2015/06/21
Silencing C19-GA 2-oxidases induces parthenocarpic development and inhibits lateral branching in tomato plants [link]Paper   doi   link   bibtex   abstract  
Transgenic hybrid aspen trees with increased gibberellin (GA) concentrations suggest that GA acts in parallel with FLOWERING LOCUS T2 to control shoot elongation. Eriksson, M. E., Hoffman, D., Kaduk, M., Mauriat, M., & Moritz, T. New Phytologist, 205(3): 1288–1295. 2015. _eprint: https://nph.onlinelibrary.wiley.com/doi/pdf/10.1111/nph.13144
Transgenic hybrid aspen trees with increased gibberellin (GA) concentrations suggest that GA acts in parallel with FLOWERING LOCUS T2 to control shoot elongation [link]Paper   doi   link   bibtex   abstract  
  2014 (9)
A quantitative LC/MS method targeting urinary 1-methyl-4-imidazoleacetic acid for safety monitoring of the global histamine turnover in clinical studies. Kolmert, J., Forngren, B., Lindberg, J., Öhd, J., Åberg, K. M., Nilsson, G., Moritz, T., & Nordström, A. Analytical and Bioanalytical Chemistry, 406(6): 1751–1762. February 2014.
A quantitative LC/MS method targeting urinary 1-methyl-4-imidazoleacetic acid for safety monitoring of the global histamine turnover in clinical studies [link]Paper   doi   link   bibtex  
Aspen pectate lyase PtxtPL1-27 mobilizes matrix polysaccharides from woody tissues and improves saccharification yield. Biswal, A. K, Soeno, K., Gandla, M., Immerzeel, P., Pattathil, S., Lucenius, J., Serimaa, R., Hahn, M. G, Moritz, T., Jönsson, L. J, Israelsson-Nordström, M., & Mellerowicz, E. J Biotechnology for Biofuels, 7(1): 11. 2014.
Aspen pectate lyase PtxtPL1-27 mobilizes matrix polysaccharides from woody tissues and improves saccharification yield [link]Paper   doi   link   bibtex  
CHOLINE TRANSPORTER-LIKE1 is required for sieve plate development to mediate long-distance cell-to-cell communication. Dettmer, J., Ursache, R., Campilho, A., Miyashima, S., Belevich, I., O’Regan, S., Mullendore, D. L., Yadav, S. R., Lanz, C., Beverina, L., Papagni, A., Schneeberger, K., Weigel, D., Stierhof, Y., Moritz, T., Knoblauch, M., Jokitalo, E., & Helariutta, Y. Nature Communications, 5(1): 4276. September 2014.
CHOLINE TRANSPORTER-LIKE1 is required for sieve plate development to mediate long-distance cell-to-cell communication [link]Paper   doi   link   bibtex  
Gibberellins inhibit adventitious rooting in hybrid aspen and Arabidopsis by affecting auxin transport. Mauriat, M., Petterle, A., Bellini, C., & Moritz, T. The Plant Journal, 78(3): 372–384. May 2014.
Gibberellins inhibit adventitious rooting in hybrid aspen and Arabidopsis by affecting auxin transport [link]Paper   doi   link   bibtex  
High lipid order of Arabidopsis cell‐plate membranes mediated by sterol and DYNAMIN‐RELATED PROTEIN1A function. Frescatada‐Rosa, M., Stanislas, T., Backues, S. K., Reichardt, I., Men, S., Boutté, Y., Jürgens, G., Moritz, T., Bednarek, S. Y., & Grebe, M. The Plant Journal, 80(5): 745–757. December 2014.
High lipid order of Arabidopsis cell‐plate membranes mediated by sterol and DYNAMIN‐RELATED PROTEIN1A function [link]Paper   doi   link   bibtex  
Maladjusted Host Immune Responses Induce Experimental Cerebral Malaria-Like Pathology in a Murine Borrelia and Plasmodium Co-Infection Model. Normark, J., Nelson, M., Engström, P., Andersson, M., Björk, R., Moritz, T., Fahlgren, A., & Bergström, S. PLoS ONE, 9(7): e103295. July 2014.
Maladjusted Host Immune Responses Induce Experimental Cerebral Malaria-Like Pathology in a Murine Borrelia and Plasmodium Co-Infection Model [link]Paper   doi   link   bibtex  
Metabolite and Peptide Levels in Plasma and CSF Differentiating Healthy Controls from Patients with Newly Diagnosed Parkinson's Disease. Trupp, M., Jonsson, P., Öhrfelt, A., Zetterberg, H., Obudulu, O., Malm, L., Wuolikainen, A., Linder, J., Moritz, T., Blennow, K., Antti, H., & Forsgren, L. Journal of Parkinson's Disease, 4(3): 549–560. 2014.
Metabolite and Peptide Levels in Plasma and CSF Differentiating Healthy Controls from Patients with Newly Diagnosed Parkinson's Disease [link]Paper   doi   link   bibtex  
No Evidence of Geographical Structure of Salicinoid Chemotypes within Populus Tremula. Keefover-Ring, K., Ahnlund, M., Abreu, I. N., Jansson, S., Moritz, T., & Albrectsen, B. R. PLoS ONE, 9(10): e107189. October 2014.
No Evidence of Geographical Structure of Salicinoid Chemotypes within Populus Tremula [link]Paper   doi   link   bibtex  
Serum Metabolomic Biomarkers of Dementia. Mousavi, M., Jonsson, P., Antti, H., Adolfsson, R., Nordin, A., Bergdahl, J., Eriksson, K., Moritz, T., Nilsson, L., & Nyberg, L. Dementia and Geriatric Cognitive Disorders Extra, 4(2): 252–262. July 2014.
Serum Metabolomic Biomarkers of Dementia [link]Paper   doi   link   bibtex  
  2013 (4)
ABCG9, ABCG11 and ABCG14 ABC transporters are required for vascular development in Arabidopsis. Le Hir, R., Sorin, C., Chakraborti, D., Moritz, T., Schaller, H., Tellier, F., Robert, S., Morin, H., Bakó, L., & Bellini, C. The Plant Journal, 76(5): 811–824. December 2013.
ABCG9, ABCG11 and ABCG14 ABC transporters are required for vascular development in Arabidopsis [link]Paper   doi   link   bibtex  
Co-expression analysis, proteomic and metabolomic study on the impact of a Deg/HtrA protease triple mutant in Synechocystis sp. PCC 6803 exposed to temperature and high light stress. Miranda, H., Cheregi, O., Netotea, S., Hvidsten, T. R., Moritz, T., & Funk, C. Journal of Proteomics, 78: 294–311. January 2013.
Co-expression analysis, proteomic and metabolomic study on the impact of a Deg/HtrA protease triple mutant in Synechocystis sp. PCC 6803 exposed to temperature and high light stress [link]Paper   doi   link   bibtex  
OnPLS integration of transcriptomic, proteomic and metabolomic data shows multi-level oxidative stress responses in the cambium of transgenic hipI- superoxide dismutase Populus plants. Srivastava, V., Obudulu, O., Bygdell, J., Löfstedt, T., Rydén, P., Nilsson, R., Ahnlund, M., Johansson, A., Jonsson, P., Freyhult, E., Qvarnström, J., Karlsson, J., Melzer, M., Moritz, T., Trygg, J., Hvidsten, T. R., & Wingsle, G. BMC Genomics, 14(1): 893. December 2013.
OnPLS integration of transcriptomic, proteomic and metabolomic data shows multi-level oxidative stress responses in the cambium of transgenic hipI- superoxide dismutase Populus plants [link]Paper   doi   link   bibtex   abstract  
The effect of carbohydrates and osmoticum on storage reserve accumulation and germination of Norway spruce somatic embryos. Businge, E., Bygdell, J., Wingsle, G., Moritz, T., & Egertsdotter, U. Physiologia Plantarum, 149(2): 273–285. October 2013.
The effect of carbohydrates and osmoticum on storage reserve accumulation and germination of Norway spruce somatic embryos [link]Paper   doi   link   bibtex   1 download  
  2012 (9)
ALS patients with mutations in the SOD1 gene have an unique metabolomic profile in the cerebrospinal fluid compared with ALS patients without mutations. Wuolikainen, A., Andersen, P. M., Moritz, T., Marklund, S. L., & Antti, H. Molecular Genetics and Metabolism, 105(3): 472–478. March 2012.
ALS patients with mutations in the SOD1 gene have an unique metabolomic profile in the cerebrospinal fluid compared with ALS patients without mutations [link]Paper   doi   link   bibtex  
Altered Metabolic Signature in Pre-Diabetic NOD Mice. Madsen, R., Banday, V. S., Moritz, T., Trygg, J., & Lejon, K. PLoS ONE, 7(4): e35445. April 2012.
Altered Metabolic Signature in Pre-Diabetic NOD Mice [link]Paper   doi   link   bibtex  
Development of a gas chromatography/mass spectrometry based metabolomics protocol by means of statistical experimental design. Danielsson, A. P. H., Moritz, T., Mulder, H., & Spégel, P. Metabolomics, 8(1): 50–63. February 2012.
Development of a gas chromatography/mass spectrometry based metabolomics protocol by means of statistical experimental design [link]Paper   doi   link   bibtex  
Effects of oestrogen and testosterone therapy on serum metabolites in postmenopausal women. Zang, H., Moritz, T., Norstedt, G., Hirschberg, A. L., & Tollet-Egnell, P. Clinical Endocrinology, 77(2): 288–295. August 2012.
Effects of oestrogen and testosterone therapy on serum metabolites in postmenopausal women [link]Paper   doi   link   bibtex  
Mass spectrometric identification of new minor indigoids in shellfish purple dye from Hexaplex trunculus. Surowiec, I., Nowik, W., & Moritz, T. Dyes and Pigments, 94(2): 363–369. August 2012.
Mass spectrometric identification of new minor indigoids in shellfish purple dye from Hexaplex trunculus [link]Paper   doi   link   bibtex  
Metabolic Responses to Change in Disease Activity during Tumor Necrosis Factor Inhibition in Patients with Rheumatoid Arthritis. Madsen, R., Rantapää-Dahlqvist, S., Lundstedt, T., Moritz, T., & Trygg, J. Journal of Proteome Research, 11(7): 3796–3804. July 2012.
Metabolic Responses to Change in Disease Activity during Tumor Necrosis Factor Inhibition in Patients with Rheumatoid Arthritis [link]Paper   doi   link   bibtex  
Metabolite profiling reveals clear metabolic changes during somatic embryo development of Norway spruce (Picea abies). Businge, E., Brackmann, K., Moritz, T., & Egertsdotter, U. Tree Physiology, 32(2): 232–244. February 2012.
Metabolite profiling reveals clear metabolic changes during somatic embryo development of Norway spruce (Picea abies) [link]Paper   doi   link   bibtex  
Multivariate curve resolution provides a high-throughput data processing pipeline for pyrolysis-gas chromatography/mass spectrometry. Gerber, L., Eliasson, M., Trygg, J., Moritz, T., & Sundberg, B. Journal of Analytical and Applied Pyrolysis, 95: 95–100. May 2012.
Multivariate curve resolution provides a high-throughput data processing pipeline for pyrolysis-gas chromatography/mass spectrometry [link]Paper   doi   link   bibtex  
Physical fitness level is reflected by alterations in the human plasma metabolome. Chorell, E., Svensson, M. B., Moritz, T., & Antti, H. Molecular BioSystems, 8(4): 1187. 2012.
Physical fitness level is reflected by alterations in the human plasma metabolome [link]Paper   doi   link   bibtex  
  2011 (6)
Comparison of the role of gibberellins and ethylene in response to submergence of two lowland rice cultivars, Senia and Bomba. Dubois, V., Moritz, T., & García-Martínez, J. L. Journal of Plant Physiology, 168(3): 233–241. February 2011.
Comparison of the role of gibberellins and ethylene in response to submergence of two lowland rice cultivars, Senia and Bomba [link]Paper   doi   link   bibtex  
Diagnostic properties of metabolic perturbations in rheumatoid arthritis. Madsen, R. K, Lundstedt, T., Gabrielsson, J., Sennbro, C., Alenius, G., Moritz, T., Rantapää-Dahlqvist, S., & Trygg, J. Arthritis Research & Therapy, 13(1): R19. February 2011.
Diagnostic properties of metabolic perturbations in rheumatoid arthritis [link]Paper   doi   link   bibtex  
Disease-Related Changes in the Cerebrospinal Fluid Metabolome in Amyotrophic Lateral Sclerosis Detected by GC/TOFMS. Wuolikainen, A., Moritz, T., Marklund, S. L., Antti, H., & Andersen, P. M. PLOS ONE, 6(4): e17947. April 2011. Publisher: Public Library of Science
Disease-Related Changes in the Cerebrospinal Fluid Metabolome in Amyotrophic Lateral Sclerosis Detected by GC/TOFMS [link]Paper   doi   link   bibtex   abstract  
Proper gibberellin localization in vascular tissue is required to control auxin-dependent leaf development and bud outgrowth in hybrid aspen: GA-dependent auxin transport in vascular tissue. Mauriat, M., Sandberg, L. G., & Moritz, T. The Plant Journal, 67(5): 805–816. September 2011.
Proper gibberellin localization in vascular tissue is required to control auxin-dependent leaf development and bud outgrowth in hybrid aspen: GA-dependent auxin transport in vascular tissue [link]Paper   doi   link   bibtex  
The sucrose‐regulated Arabidopsis transcription factor bZIP11 reprograms metabolism and regulates trehalose metabolism. Ma, J., Hanssen, M., Lundgren, K., Hernández, L., Delatte, T., Ehlert, A., Liu, C., Schluepmann, H., Dröge‐Laser, W., Moritz, T., Smeekens, S., & Hanson, J. New Phytologist, 191(3): 733–745. August 2011.
The sucrose‐regulated Arabidopsis transcription factor bZIP11 reprograms metabolism and regulates trehalose metabolism [link]Paper   doi   link   bibtex  
UHPLC-ESI/TOFMS Determination of salicylate-like phenolic gycosides in Populus tremula leaves. Abreu, I., Ahnlund, M., Moritz, T., & Albrectsen, B. Journal of chemical ecology, 37: 857–70. August 2011.
doi   link   bibtex   abstract  
  2010 (8)
A Metabolomic Approach to Study Major Metabolite Changes during Acclimation to Limiting CO2 in Chlamydomonas reinhardtii. Renberg, L., Johansson, A. I., Shutova, T., Stenlund, H., Aksmann, A., Raven, J. A., Gardeström, P., Moritz, T., & Samuelsson, G. Plant Physiology, 154(1): 187–196. September 2010.
A Metabolomic Approach to Study Major Metabolite Changes during Acclimation to Limiting CO2 in <i>Chlamydomonas reinhardtii</i> [link]Paper   doi   link   bibtex   abstract  
Alteration of PHYA expression change circadian rhythms and timing of bud set in Populus. Kozarewa, I., Ibáñez, C., Johansson, M., Ögren, E., Mozley, D., Nylander, E., Chono, M., Moritz, T., & Eriksson, M. E. Plant Molecular Biology, 73(1-2): 143–156. May 2010.
Alteration of PHYA expression change circadian rhythms and timing of bud set in Populus [link]Paper   doi   link   bibtex  
Changes in diurnal patterns within the Populus transcriptome and metabolome in response to photoperiod variation. Hoffman, D. E., Jonsson, P., Bylesjö, M., Trygg, J., Antti, H., Eriksson, M. E., & Moritz, T. Plant, Cell & Environment, 33(8): 1298–1313. August 2010.
doi   link   bibtex   abstract   1 download  
Development and optimization of a metabolomic method for analysis of adherent cell cultures. Danielsson, A. P., Moritz, T., Mulder, H., & Spégel, P. Analytical Biochemistry, 404(1): 30–39. September 2010.
Development and optimization of a metabolomic method for analysis of adherent cell cultures [link]Paper   doi   link   bibtex  
Ischaemic preconditioning is related to decreasing levels of extracellular adenosine that may be metabolically useful in the at-risk myocardium: an experimental study in the pig. Waldenström, A., Haney, M., Biber, B., Kavianipour, M., Moritz, T., Strandén, P., Wikström, G., & Ronquist, G. Acta Physiologica, 199(1): 1–9. May 2010.
Ischaemic preconditioning is related to decreasing levels of extracellular adenosine that may be metabolically useful in the at-risk myocardium: an experimental study in the pig [link]Paper   doi   link   bibtex  
Metabolomic Characterization of Human Prostate Cancer Bone Metastases Reveals Increased Levels of Cholesterol. Thysell, E., Surowiec, I., Hörnberg, E., Crnalic, S., Widmark, A., Johansson, A. I., Stattin, P., Bergh, A., Moritz, T., Antti, H., & Wikström, P. PLoS ONE, 5(12): e14175. December 2010.
Metabolomic Characterization of Human Prostate Cancer Bone Metastases Reveals Increased Levels of Cholesterol [link]Paper   doi   link   bibtex  
Metabolomic analysis of a human oral glucose tolerance test reveals fatty acids as reliable indicators of regulated metabolism. Spégel, P., Danielsson, A. P. H., Bacos, K., Nagorny, C. L. F., Moritz, T., Mulder, H., & Filipsson, K. Metabolomics, 6(1): 56–66. March 2010.
Metabolomic analysis of a human oral glucose tolerance test reveals fatty acids as reliable indicators of regulated metabolism [link]Paper   doi   link   bibtex  
Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal β-cells. Krus, U., Kotova, O., Spégel, P., Hallgard, E., Sharoyko, V., Vedin, A., Moritz, T., Sugden, M., Koeck, T., & Mulder, H. Biochemical Journal, 429(1): 205–213. July 2010.
Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal β-cells [link]Paper   doi   link   bibtex   abstract  
  2009 (11)
An Auxin Gradient and Maximum in the Arabidopsis Root Apex Shown by High-Resolution Cell-Specific Analysis of IAA Distribution and Synthesis. Petersson, S. V., Johansson, A. I., Kowalczyk, M., Makoveychuk, A., Wang, J. Y., Moritz, T., Grebe, M., Benfey, P. N., Sandberg, G., & Ljung, K. The Plant Cell, 21(6): 1659–1668. August 2009.
An Auxin Gradient and Maximum in the <i>Arabidopsis</i> Root Apex Shown by High-Resolution Cell-Specific Analysis of IAA Distribution and Synthesis [link]Paper   doi   link   bibtex   abstract   1 download  
Analyses of GA20ox- and GID1-over-expressing aspen suggest that gibberellins play two distinct roles in wood formation. Mauriat, M., & Moritz, T. The Plant Journal: For Cell and Molecular Biology, 58(6): 989–1003. June 2009.
doi   link   bibtex   abstract  
Compensation for Systematic Cross-Contribution Improves Normalization of Mass Spectrometry Based Metabolomics Data. Redestig, H., Fukushima, A., Stenlund, H., Moritz, T., Arita, M., Saito, K., & Kusano, M. Analytical Chemistry, 81(19): 7974–7980. October 2009.
Compensation for Systematic Cross-Contribution Improves Normalization of Mass Spectrometry Based Metabolomics Data [link]Paper   doi   link   bibtex  
Decreased Mitochondrial Activities of Malate Dehydrogenase and Fumarase in Tomato Lead to Altered Root Growth and Architecture via Diverse Mechanisms. van der Merwe, M. J., Osorio, S., Moritz, T., Nunes-Nesi, A., & Fernie, A. R. Plant Physiology, 149(2): 653–669. February 2009.
Decreased Mitochondrial Activities of Malate Dehydrogenase and Fumarase in Tomato Lead to Altered Root Growth and Architecture via Diverse Mechanisms [link]Paper   doi   link   bibtex   abstract  
Gibberellin mediates daylength-controlled differentiation of vegetative meristems in strawberry (Fragaria × ananassa Duch). Hytönen, T., Elomaa, P., Moritz, T., & Junttila, O. BMC Plant Biology, 9(1): 18. 2009.
Gibberellin mediates daylength-controlled differentiation of vegetative meristems in strawberry (Fragaria × ananassa Duch) [link]Paper   doi   link   bibtex  
Improper excess light energy dissipation in Arabidopsis results in a metabolic reprogramming. Frenkel, M., Külheim, C., Jänkänpää, H. J., Skogström, O., Dall'Osto, L., Ågren, J., Bassi, R., Moritz, T., Moen, J., & Jansson, S. BMC Plant Biology, 9(1): 12. January 2009.
Improper excess light energy dissipation in Arabidopsis results in a metabolic reprogramming [link]Paper   doi   link   bibtex   abstract  
Integrated Analysis of Transcript, Protein and Metabolite Data To Study Lignin Biosynthesis in Hybrid Aspen. Bylesjö, M., Nilsson, R., Srivastava, V., Grönlund, A., Johansson, A. I., Jansson, S., Karlsson, J., Moritz, T., Wingsle, G., & Trygg, J. Journal of Proteome Research, 8(1): 199–210. January 2009.
Integrated Analysis of Transcript, Protein and Metabolite Data To Study Lignin Biosynthesis in Hybrid Aspen [link]Paper   doi   link   bibtex  
Metabolomic evaluation of pulsed electric field-induced stress on potato tissue. Galindo, F. G., Dejmek, P., Lundgren, K., Rasmusson, A. G., Vicente, A., & Moritz, T. Planta, 230(3): 469–479. August 2009.
Metabolomic evaluation of pulsed electric field-induced stress on potato tissue [link]Paper   doi   link   bibtex  
Optimization of procedures for collecting and storing of CSF for studying the metabolome in ALS. Wuolikainen, A., Hedenström, M., Moritz, T., Marklund, S. L., Antti, H., & Andersen, P. M. Amyotrophic Lateral Sclerosis, 10(4): 229–236. January 2009.
Optimization of procedures for collecting and storing of CSF for studying the metabolome in ALS [link]Paper   doi   link   bibtex  
Predictive Metabolomics Evaluation of Nutrition-Modulated Metabolic Stress Responses in Human Blood Serum During the Early Recovery Phase of Strenuous Physical Exercise. Chorell, E., Moritz, T., Branth, S., Antti, H., & Svensson, M. B. Journal of Proteome Research, 8(6): 2966–2977. June 2009.
Predictive Metabolomics Evaluation of Nutrition-Modulated Metabolic Stress Responses in Human Blood Serum During the Early Recovery Phase of Strenuous Physical Exercise [link]Paper   doi   link   bibtex  
The role and regulation of the tricarboxylic acid cycle in Solanum lycopersicum roots. Van der Merwe, M., Osorio, S., Moritz, T., Nunes-Nesi, A., & Fernie, A. South African Journal of Botany, 75(2): 424. April 2009.
The role and regulation of the tricarboxylic acid cycle in Solanum lycopersicum roots [link]Paper   doi   link   bibtex  
  2008 (9)
A Second Pathway to Degrade Pyrimidine Nucleic Acid Precursors in Eukaryotes. Andersen, G., Björnberg, O., Polakova, S., Pynyaha, Y., Rasmussen, A., Møller, K., Hofer, A., Moritz, T., Sandrini, M. P. B., Merico, A., Compagno, C., Åkerlund, H., Gojković, Z., & Piškur, J. Journal of Molecular Biology, 380(4): 656–666. July 2008.
A Second Pathway to Degrade Pyrimidine Nucleic Acid Precursors in Eukaryotes [link]Paper   doi   link   bibtex  
Arabidopsis sterol carrier protein-2 is required for normal development of seeds and seedlings. Zheng, B. S., Rönnberg, E., Viitanen, L., Salminen, T. A., Lundgren, K., Moritz, T., & Edqvist, J. Journal of Experimental Botany, 59(12): 3485–3499. September 2008.
Arabidopsis sterol carrier protein-2 is required for normal development of seeds and seedlings [link]Paper   doi   link   bibtex  
Evaluation of a protocol for metabolic profiling studies on human blood plasma by combined ultra-performance liquid chromatography/mass spectrometry: From extraction to data analysis. Bruce, S. J., Jonsson, P., Antti, H., Cloarec, O., Trygg, J., Marklund, S. L., & Moritz, T. Analytical Biochemistry, 372(2): 237–249. January 2008.
Evaluation of a protocol for metabolic profiling studies on human blood plasma by combined ultra-performance liquid chromatography/mass spectrometry: From extraction to data analysis [link]Paper   doi   link   bibtex  
Gibberellin Homeostasis in Tobacco is Regulated by Gibberellin Metabolism Genes with Different Gibberellin Sensitivity. Gallego-Giraldo, L., Ubeda-Tomás, S., Gisbert, C., García-Martínez, J. L., Moritz, T., & López-Díaz, I. Plant and Cell Physiology, 49(5): 679–690. May 2008.
Gibberellin Homeostasis in Tobacco is Regulated by Gibberellin Metabolism Genes with Different Gibberellin Sensitivity [link]Paper   doi   link   bibtex  
Modulation of the Hormone Setting by Rhodococcus fascians Results in Ectopic KNOX Activation in Arabidopsis. Depuydt, S., Doležal, K., Van Lijsebettens, M., Moritz, T., Holsters, M., & Vereecke, D. Plant Physiology, 146(3): 1267–1281. March 2008.
Modulation of the Hormone Setting by <i>Rhodococcus fascians</i> Results in Ectopic <i>KNOX</i> Activation in Arabidopsis [link]Paper   doi   link   bibtex   abstract  
Reduced gibberellin response affects ethylene biosynthesis and responsiveness in the Arabidopsis gai eto2‐1 double mutant. De Grauwe, L., Chaerle, L., Dugardeyn, J., Decat, J., Rieu, I., Vriezen, W. H., Moritz, T., Beemster, G. T. S., Phillips, A. L., Harberd, N. P., Hedden, P., & Van Der Straeten, D. New Phytologist, 177(1): 128–141. January 2008.
Reduced gibberellin response affects ethylene biosynthesis and responsiveness in the Arabidopsis <i>gai eto2‐1</i> double mutant [link]Paper   doi   link   bibtex  
Sterol-dependent endocytosis mediates post-cytokinetic acquisition of PIN2 auxin efflux carrier polarity. Men, S., Boutté, Y., Ikeda, Y., Li, X., Palme, K., Stierhof, Y., Hartmann, M., Moritz, T., & Grebe, M. Nature Cell Biology, 10(2): 237–244. February 2008.
Sterol-dependent endocytosis mediates post-cytokinetic acquisition of PIN2 auxin efflux carrier polarity [link]Paper   doi   link   bibtex  
The lack of a systematic validation of reference genes: a serious pitfall undervalued in reverse transcription-polymerase chain reaction (RT-PCR) analysis in plants. Gutierrez, L., Mauriat, M., Gunin, S., Pelloux, J., Lefebvre, J., Louvet, R., Rusterucci, C., Moritz, T., Guerineau, F., Bellini, C., & Van Wuytswinkel, O. Plant Biotechnology Journal, 6(6): 609–618. August 2008.
The lack of a systematic validation of reference genes: a serious pitfall undervalued in reverse transcription-polymerase chain reaction (RT-PCR) analysis in plants [link]Paper   doi   link   bibtex  
Visualization of GC/TOF-MS-Based Metabolomics Data for Identification of Biochemically Interesting Compounds Using OPLS Class Models. Wiklund, S., Johansson, E., Sjöström, L., Mellerowicz, E. J., Edlund, U., Shockcor, J. P., Gottfries, J., Moritz, T., & Trygg, J. Analytical Chemistry, 80(1): 115–122. January 2008.
Visualization of GC/TOF-MS-Based Metabolomics Data for Identification of Biochemically Interesting Compounds Using OPLS Class Models [link]Paper   doi   link   bibtex  
  2007 (10)
Application of a metabolomic method combining one-dimensional and two-dimensional gas chromatography-time-of-flight/mass spectrometry to metabolic phenotyping of natural variants in rice. Kusano, M., Fukushima, A., Kobayashi, M., Hayashi, N., Jonsson, P., Moritz, T., Ebana, K., & Saito, K. Journal of Chromatography B, 855(1): 71–79. August 2007.
Application of a metabolomic method combining one-dimensional and two-dimensional gas chromatography-time-of-flight/mass spectrometry to metabolic phenotyping of natural variants in rice [link]Paper   doi   link   bibtex  
Cross-talk between gibberellin and auxin in development of Populus wood: gibberellin stimulates polar auxin transport and has a common transcriptome with auxin: Cross-talk between GA and auxin in wood development. Björklund, S., Antti, H., Uddestrand, I., Moritz, T., & Sundberg, B. The Plant Journal, 52(3): 499–511. September 2007.
Cross-talk between gibberellin and auxin in development of Populus wood: gibberellin stimulates polar auxin transport and has a common transcriptome with auxin: Cross-talk between GA and auxin in wood development [link]Paper   doi   link   bibtex  
Data integration in plant biology: the O2PLS method for combined modeling of transcript and metabolite data. Bylesjö, M., Eriksson, D., Kusano, M., Moritz, T., & Trygg, J. The Plant Journal, 52(6): 1181–1191. December 2007.
Data integration in plant biology: the O2PLS method for combined modeling of transcript and metabolite data [link]Paper   doi   link   bibtex  
Environmental and hormonal regulation of the activity-dormancy cycle in the cambial meristem involves stage-specific modulation of transcriptional and metabolic networks: Molecular analysis of cambial activity-dormancy cycle. Druart, N., Johansson, A., Baba, K., Schrader, J., Sjödin, A., Bhalerao, R. R., Resman, L., Trygg, J., Moritz, T., & Bhalerao, R. P. The Plant Journal, 50(4): 557–573. April 2007.
Environmental and hormonal regulation of the activity-dormancy cycle in the cambial meristem involves stage-specific modulation of transcriptional and metabolic networks: Molecular analysis of cambial activity-dormancy cycle [link]Paper   doi   link   bibtex  
Ethylene-induced Arabidopsis hypocotyl elongation is dependent on but not mediated by gibberellins. Vandenbussche, F., Vancompernolle, B., Rieu, I., Ahmad, M., Phillips, A., Moritz, T., Hedden, P., & Van Der Straeten, D. Journal of Experimental Botany, 58(15-16): 4269–4281. November 2007.
Ethylene-induced Arabidopsis hypocotyl elongation is dependent on but not mediated by gibberellins [link]Paper   doi   link   bibtex  
Orthogonal projections to latent structures as a strategy for microarray data normalization. Bylesjö, M., Eriksson, D., Sjödin, A., Jansson, S., Moritz, T., & Trygg, J. BMC Bioinformatics, 8(1): 207. December 2007.
Orthogonal projections to latent structures as a strategy for microarray data normalization [link]Paper   doi   link   bibtex  
Plant metabolomics coming of age. Guy, C., Kopka, J., & Moritz, T. Physiologia Plantarum, 132(2): 113–116. December 2007.
Plant metabolomics coming of age [link]Paper   doi   link   bibtex  
Reliable Profile Detection in Comparative Metabolomics. Thysell, E., Pohjanen, E., Lindberg, J., Schuppe-Koistinen, I., Moritz, T., Jonsson, P., & Antti, H. OMICS: A Journal of Integrative Biology, 11(2): 209–224. June 2007.
Reliable Profile Detection in Comparative Metabolomics [link]Paper   doi   link   bibtex  
The plant stress hormone ethylene controls floral transition via DELLA-dependent regulation of floral meristem-identity genes. Achard, P., Baghour, M., Chapple, A., Hedden, P., Van Der Straeten, D., Genschik, P., Moritz, T., & Harberd, N. P. Proceedings of the National Academy of Sciences, 104(15): 6484–6489. April 2007.
The plant stress hormone ethylene controls floral transition via DELLA-dependent regulation of floral meristem-identity genes [link]Paper   doi   link   bibtex  
Unbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana. Kusano, M., Fukushima, A., Arita, M., Jonsson, P., Moritz, T., Kobayashi, M., Hayashi, N., Tohge, T., & Saito, K. BMC Systems Biology, 1(1): 53. 2007.
Unbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana [link]Paper   doi   link   bibtex  
  2006 (10)
Arabidopsis REGULATOR OF AXILLARY MERISTEMS1 controls a leaf axil stem cell niche and modulates vegetative development. Keller, T., Abbott, J., Moritz, T., & Doerner, P. Plant Cell, 18(3): 598–611. March 2006. Place: Rockville Publisher: Amer Soc Plant Biologists WOS:000236004900009
doi   link   bibtex   abstract  
Biosynthesis of cellulose-enriched tension wood in Populus: global analysis of transcripts and metabolites identifies biochemical and developmental regulators in secondary wall biosynthesis. Andersson-Gunnerås, S., Mellerowicz, E. J., Love, J., Segerman, B., Ohmiya, Y., Coutinho, P. M., Nilsson, P., Henrissat, B., Moritz, T., & Sundberg, B. The Plant Journal, 45(2): 144–165. 2006. _eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-313X.2005.02584.x
Biosynthesis of cellulose-enriched tension wood in Populus: global analysis of transcripts and metabolites identifies biochemical and developmental regulators in secondary wall biosynthesis [link]Paper   doi   link   bibtex   abstract  
GA4 Is the Active Gibberellin in the Regulation of LEAFY Transcription and Arabidopsis Floral Initiation. Eriksson, S., Böhlenius, H., Moritz, T., & Nilsson, O. The Plant Cell, 18(9): 2172–2181. September 2006.
GA4 Is the Active Gibberellin in the Regulation of LEAFY Transcription and Arabidopsis Floral Initiation [link]Paper   doi   link   bibtex   abstract  
Integration of plant responses to environmentally activated phytohormonal signals. Achard, P., Cheng, H., De Grauwe, L., Decat, J., Schoutteten, H., Moritz, T., Van Der Straeten, D., Peng, J. R., & Harberd, N. P. Science, 311(5757): 91–94. January 2006. Place: Washington Publisher: Amer Assoc Advancement Science WOS:000234546300040
doi   link   bibtex   abstract  
Long-term submergence-induced elongation in Rumex palustris requires abscisic acid-dependent biosynthesis of gibberellin. Benschop, J. J., Bou, J., Peeters, A. J. M., Wagemaker, N., Guhl, K., Ward, D., Hedden, P., Moritz, T., & Voesenek, L. A. C. J. Plant Physiology, 141(4): 1644–1652. August 2006. Place: Rockville Publisher: Amer Soc Plant Biologists WOS:000239636800044
doi   link   bibtex   abstract  
MASQOT-GUI: spot quality assessment for the two-channel microarray platform. Bylesjö, M., Sjödin, A., Eriksson, D., Antti, H., Moritz, T., Jansson, S., & Trygg, J. Bioinformatics, 22(20): 2554–2555. October 2006.
MASQOT-GUI: spot quality assessment for the two-channel microarray platform [link]Paper   doi   link   bibtex   abstract  
Predictive metabolite profiling applying hierarchical multivariate curve resolution to GC-MS datas - A potential tool for multi-parametric diagnosis. Jonsson, P., Johansson, E. S., Wuolikainen, A., Lindberg, J., Schuppe-Koistinen, I., Kusano, M., Sjostrom, M., Trygg, J., Moritz, T., & Antti, H. Journal of Proteome Research, 5(6): 1407–1414. June 2006. Place: Washington Publisher: Amer Chemical Soc WOS:000237973400012
doi   link   bibtex   abstract  
Regulation of flowering in the long-day grass Lolium temulentum by Gibberellins and the FLOWERING LOCUS T gene. King, R. W., Moritz, T., Evans, L. T., Martin, J., Andersen, C. H., Blundell, C., Kardailsky, I., & Chandler, P. M. Plant Physiology, 141(2): 498–507. June 2006. Place: Rockville Publisher: Amer Soc Plant Biologists WOS:000238168800025
doi   link   bibtex   abstract  
Statistical multivariate metabolite profiling for aiding biomarker pattern detection and mechanistic interpretations in GC/MS based metabolomics. Pohjanen, E., Thysell, E., Lindberg, J., Schuppe-Koistinen, I., Moritz, T., Jonsson, P., & Antti, H. Metabolomics, 2(4): 257–268. December 2006.
Statistical multivariate metabolite profiling for aiding biomarker pattern detection and mechanistic interpretations in GC/MS based metabolomics [link]Paper   doi   link   bibtex   abstract  
Transitions in the functioning of the shoot apical meristem in birch (Betula pendula) involve ethylene. Ruonala, R., Rinne, P. L. H., Baghour, M., Moritz, T., Tuominen, H., & Kangasjarvi, J. Plant Journal, 46(4): 628–640. May 2006. Place: Hoboken Publisher: Wiley WOS:000237098000008
doi   link   bibtex   abstract  
  2005 (5)
Extraction and GC/MS Analysis of the Human Blood Plasma Metabolome. A, J., Trygg, J., Gullberg, J., Johansson, A. I., Jonsson, P., Antti, H., Marklund, S. L., & Moritz, T. Analytical Chemistry, 77(24): 8086–8094. December 2005. Publisher: American Chemical Society
Extraction and GC/MS Analysis of the Human Blood Plasma Metabolome [link]Paper   doi   link   bibtex   abstract  
Extraction, interpretation and validation of information for comparing samples in metabolic LC/MS data sets. Jonsson, P., Bruce, S. J., Moritz, T., Trygg, J., Sjöström, M., Plumb, R., Granger, J., Maibaum, E., Nicholson, J. K., Holmes, E., & Antti, H. Analyst, 130(5): 701–707. April 2005. Publisher: The Royal Society of Chemistry
Extraction, interpretation and validation of information for comparing samples in metabolic LC/MS data sets [link]Paper   doi   link   bibtex   abstract  
GC–MS libraries for the rapid identification of metabolites in complex biological samples. Schauer, N., Steinhauser, D., Strelkov, S., Schomburg, D., Allison, G., Moritz, T., Lundgren, K., Roessner-Tunali, U., Forbes, M. G., Willmitzer, L., Fernie, A. R., & Kopka, J. FEBS Letters, 579(6): 1332–1337. 2005.
GC–MS libraries for the rapid identification of metabolites in complex biological samples [link]Paper   doi   link   bibtex   abstract  
High-Throughput Data Analysis for Detecting and Identifying Differences between Samples in GC/MS-Based Metabolomic Analyses. Jonsson, P., Johansson, A. I., Gullberg, J., Trygg, J., A, J., Grung, B., Marklund, S., Sjöström, M., Antti, H., & Moritz, T. Analytical Chemistry, 77(17): 5635–5642. September 2005. Publisher: American Chemical Society
High-Throughput Data Analysis for Detecting and Identifying Differences between Samples in GC/MS-Based Metabolomic Analyses [link]Paper   doi   link   bibtex   abstract  
Tissue-specific localization of gibberellins and expression of gibberellin-biosynthetic and signaling genes in wood-forming tissues in aspen. Israelsson, M., Sundberg, B., & Moritz, T. The Plant Journal, 44(3): 494–504. 2005. _eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-313X.2005.02547.x
Tissue-specific localization of gibberellins and expression of gibberellin-biosynthetic and signaling genes in wood-forming tissues in aspen [link]Paper   doi   link   bibtex   abstract  
  2004 (8)
A Strategy for Identifying Differences in Large Series of Metabolomic Samples Analyzed by GC/MS. Jonsson, P., Gullberg, J., Nordström, A., Kusano, M., Kowalczyk, M., Sjöström, M., & Moritz, T. Analytical Chemistry, 76(6): 1738–1745. March 2004. Publisher: American Chemical Society
A Strategy for Identifying Differences in Large Series of Metabolomic Samples Analyzed by GC/MS [link]Paper   doi   link   bibtex   abstract  
AtGA3ox2, a Key Gene Responsible for Bioactive Gibberellin Biosynthesis, Is Regulated during Embryogenesis by LEAFY COTYLEDON2 and FUSCA3 in Arabidopsis. Curaba, J., Moritz, T., Blervaque, R., Parcy, F., Raz, V., Herzog, M., & Vachon, G. Plant Physiology, 136(3): 3660–3669. November 2004.
AtGA3ox2, a Key Gene Responsible for Bioactive Gibberellin Biosynthesis, Is Regulated during Embryogenesis by LEAFY COTYLEDON2 and FUSCA3 in Arabidopsis [link]Paper   doi   link   bibtex   abstract  
Cloning and Overproduction of Gibberellin 3-Oxidase in Hybrid Aspen Trees. Effects on Gibberellin Homeostasis and Development. Israelsson, M., Mellerowicz, E., Chono, M., Gullberg, J., & Moritz, T. Plant Physiology, 135(1): 221–230. May 2004.
Cloning and Overproduction of Gibberellin 3-Oxidase in Hybrid Aspen Trees. Effects on Gibberellin Homeostasis and Development [link]Paper   doi   link   bibtex   abstract  
Derivatization for LC-Electrospray Ionization-MS:  A Tool for Improving Reversed-Phase Separation and ESI Responses of Bases, Ribosides, and Intact Nucleotides. Nordström, A., Tarkowski, P., Tarkowska, D., Dolezal, K., Åstot, C., Sandberg, G., & Moritz, T. Analytical Chemistry, 76(10): 2869–2877. May 2004. Publisher: American Chemical Society
Derivatization for LC-Electrospray Ionization-MS:  A Tool for Improving Reversed-Phase Separation and ESI Responses of Bases, Ribosides, and Intact Nucleotides [link]Paper   doi   link   bibtex   abstract  
Design of experiments: an efficient strategy to identify factors influencing extraction and derivatization of Arabidopsis thaliana samples in metabolomic studies with gas chromatography/mass spectrometry. Gullberg, J., Jonsson, P., Nordström, A., Sjöström, M., & Moritz, T. Analytical Biochemistry, 331(2): 283–295. August 2004.
Design of experiments: an efficient strategy to identify factors influencing extraction and derivatization of Arabidopsis thaliana samples in metabolomic studies with gas chromatography/mass spectrometry [link]Paper   doi   link   bibtex   abstract  
Gibberellins and the floral transition in Sinapis alba. Corbesier, L., Kustermans, G., Perilleux, C., Melzer, S., Moritz, T., Havelange, A., & Bernier, G. Physiologia Plantarum, 122(1): 152–158. September 2004. Place: Hoboken Publisher: Wiley WOS:000223589000018
doi   link   bibtex   abstract  
Global analysis of low-molecular-weight compounds in human plasma using GC/TOF-MS. Jiye, A., Trygg, J., Gullberg, J., Moritz, T., & Marklund, S. Drug Metabolism Reviews, 36: 246–246. August 2004. Place: Philadelphia Publisher: Taylor & Francis Inc WOS:000224023200489
link   bibtex  
The Roles of Ethylene, Auxin, Abscisic Acid, and Gibberellin in the Hyponastic Growth of Submerged Rumex palustris Petioles. Cox, M. C., Benschop, J. J., Vreeburg, R. A., Wagemaker, C. A., Moritz, T., Peeters, A. J., & Voesenek, L. A. Plant Physiology, 136(2): 2948–2960. October 2004.
The Roles of Ethylene, Auxin, Abscisic Acid, and Gibberellin in the Hyponastic Growth of Submerged Rumex palustris Petioles [link]Paper   doi   link   bibtex   abstract  
  2003 (1)
Changes in gene expression in the wood-forming tissue of transgenic hybrid aspen with increased secondary growth. Israelsson, M., Eriksson, M. E., Hertzberg, M., Aspeborg, H., Nilsson, P., & Moritz, T. Plant Molecular Biology, 52(4): 893–903. July 2003.
Changes in gene expression in the wood-forming tissue of transgenic hybrid aspen with increased secondary growth [link]Paper   doi   link   bibtex   abstract  
  2002 (3)
Daylength and spatial expression of a gibberellin 20-oxidase isolated from hybrid aspen (Populus tremula L. × P. tremuloides Michx.). Eriksson, M. E., & Moritz, T. Planta, 214(6): 920–930. April 2002.
Daylength and spatial expression of a gibberellin 20-oxidase isolated from hybrid aspen (Populus tremula L. × P. tremuloides Michx.) [link]Paper   doi   link   bibtex   abstract   1 download  
Independent Activation of Cold Acclimation by Low Temperature and Short Photoperiod in Hybrid Aspen. Welling, A., Moritz, T., Palva, E. T., & Junttila, O. Plant Physiology, 129(4): 1633–1641. August 2002.
Independent Activation of Cold Acclimation by Low Temperature and Short Photoperiod in Hybrid Aspen [link]Paper   doi   link   bibtex   abstract  
Molecular and physiological characterization of Arabidopsis GAI alleles obtained in targeted Ds-tagging experiments. Peng, J., Richards, D. E., Moritz, T., Ezura, H., Carol, P., & Harberd, N. P. Planta, 214(4): 591–596. February 2002.
Molecular and physiological characterization of Arabidopsis GAI alleles obtained in targeted Ds-tagging experiments [link]Paper   doi   link   bibtex   abstract  
  2001 (4)
Function and Dynamics of Auxin and Carbohydrates during Earlywood/Latewood Transition in Scots Pine1. Uggla, C., Magel, E., Moritz, T., & Sundberg, B. Plant Physiology, 125(4): 2029–2039. April 2001.
Function and Dynamics of Auxin and Carbohydrates during Earlywood/Latewood Transition in Scots Pine1 [link]Paper   doi   link   bibtex   abstract  
GAMYB-like Genes, Flowering, and Gibberellin Signaling in Arabidopsis. Gocal, G. F., Sheldon, C. C., Gubler, F., Moritz, T., Bagnall, D. J., MacMillan, C. P., Li, S. F., Parish, R. W., Dennis, E. S., Weigel, D., & King, R. W. Plant Physiology, 127(4): 1682–1693. December 2001.
GAMYB-like Genes, Flowering, and Gibberellin Signaling in Arabidopsis [link]Paper   link   bibtex   abstract  
Gibberellins Are Not Required for Normal Stem Growth in Arabidopsis thaliana in the Absence of GAI and RGA. King, K. E, Moritz, T., & Harberd, N. P Genetics, 159(2): 767–776. October 2001.
Gibberellins Are Not Required for Normal Stem Growth in Arabidopsis thaliana in the Absence of GAI and RGA [link]Paper   doi   link   bibtex   abstract  
Long-Day Induction of Flowering in Lolium temulentum Involves Sequential Increases in Specific Gibberellins at the Shoot Apex. King, R. W., Moritz, T., Evans, L. T., Junttila, O., & Herlt, A. J. Plant Physiology, 127(2): 624–632. October 2001.
Long-Day Induction of Flowering in Lolium temulentum Involves Sequential Increases in Specific Gibberellins at the Shoot Apex [link]Paper   link   bibtex   abstract  
  2000 (4)
An alternative cytokinin biosynthesis pathway. Åstot, C., Dolezal, K., Nordström, A., Wang, Q., Kunkel, T., Moritz, T., Chua, N., & Sandberg, G. Proceedings of the National Academy of Sciences, 97(26): 14778–14783. December 2000. Publisher: National Academy of Sciences Section: Biological Sciences
An alternative cytokinin biosynthesis pathway [link]Paper   doi   link   bibtex   abstract  
Deuterium in vivo labelling of cytokinins in Arabidopsis thaliana analysed by capillary liquid chromatography/frit-fast atom bombardment mass spectrometry. Åstot, C., Dolezal, K., Moritz, T., & Sandberg, G. Journal of Mass Spectrometry, 35(1): 13–22. 2000. _eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1002/%28SICI%291096-9888%28200001%2935%3A1%3C13%3A%3AAID-JMS901%3E3.0.CO%3B2-I
Deuterium in vivo labelling of cytokinins in Arabidopsis thaliana analysed by capillary liquid chromatography/frit-fast atom bombardment mass spectrometry [link]Paper   doi   link   bibtex   abstract  
Increased gibberellin biosynthesis in transgenic trees promotes growth, biomass production and xylem fiber length. Eriksson, M. E., Israelsson, M., Olsson, O., & Moritz, T. Nature Biotechnology, 18(7): 784–788. July 2000. Bandiera_abtest: a Cg_type: Nature Research Journals Number: 7 Primary_atype: Research Publisher: Nature Publishing Group
Increased gibberellin biosynthesis in transgenic trees promotes growth, biomass production and xylem fiber length [link]Paper   doi   link   bibtex   abstract   2 downloads  
Transgenic tobacco plants co-expressing Agrobacterium iaa and ipt genes have wild-type hormone levels but display both auxin- and cytokinin-overproducing phenotypes. Eklöf, S., Åstot, C., Sitbon, F., Moritz, T., Olsson, O., & Sandberg, G. The Plant Journal, 23(2): 279–284. 2000. _eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-313x.2000.00762.x
Transgenic tobacco plants co-expressing Agrobacterium iaa and ipt genes have wild-type hormone levels but display both auxin- and cytokinin-overproducing phenotypes [link]Paper   doi   link   bibtex   abstract  
  1999 (3)
Dwarf (di)haploid pito mutants obtained from a tetraploid potato cultivar (Solanum tuberosum subsp. tuberosum) via anther culture are defective in gibberellin biosynthesis. Valkonen, J. P. T., Moritz, T., Watanabe, K. N., & Rokka, V. Plant Science, 149(1): 51–57. November 1999.
Dwarf (di)haploid pito mutants obtained from a tetraploid potato cultivar (Solanum tuberosum subsp. tuberosum) via anther culture are defective in gibberellin biosynthesis [link]Paper   doi   link   bibtex   abstract  
Extragenic Suppressors of the Arabidopsis gaiMutation Alter the Dose-Response Relationship of Diverse Gibberellin Responses1. Peng, J., Richards, D. E., Moritz, T., Caño-Delgado, A., & Harberd, N. P. Plant Physiology, 119(4): 1199–1208. April 1999.
Extragenic Suppressors of the Arabidopsis gaiMutation Alter the Dose-Response Relationship of Diverse Gibberellin Responses1 [link]Paper   doi   link   bibtex   abstract  
The Arabidopsis Dwarf Mutant shi Exhibits Reduced Gibberellin Responses Conferred by Overexpression of a New Putative Zinc Finger Protein. Fridborg, I., Kuusk, S., Moritz, T., & Sundberg, E. The Plant Cell, 11(6): 1019–1031. June 1999.
The Arabidopsis Dwarf Mutant shi Exhibits Reduced Gibberellin Responses Conferred by Overexpression of a New Putative Zinc Finger Protein [link]Paper   doi   link   bibtex   abstract  
  1997 (2)
Ectopic expression of oat phytochrome A in hybrid aspen changes critical daylength for growth and prevents cold acclimatization. Olsen, J. E., Junttila, O., Nilsen, J., Eriksson, M. E., Martinussen, I., Olsson, O., Sandberg, G., & Moritz, T. The Plant Journal, 12(6): 1339–1350. 1997. _eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-313x.1997.12061339.x
Ectopic expression of oat phytochrome A in hybrid aspen changes critical daylength for growth and prevents cold acclimatization [link]Paper   doi   link   bibtex   abstract  
Phytochrome Overexpression and Cold Hardiness in Transgenic Populus. Junttila, O., Olsen, J. E., Nilsen, J., Martinussen, I., Moritz, T., Eriksson, M., Olsson, O., & Sandberg, G. In Li, P. H., & Chen, T. H. H., editor(s), Plant Cold Hardiness: Molecular Biology, Biochemistry, and Physiology, pages 245–255. Springer US, Boston, MA, 1997.
Phytochrome Overexpression and Cold Hardiness in Transgenic Populus [link]Paper   doi   link   bibtex   abstract  
  1996 (1)
Expression of the Agrobacterium rhizogenes rolC Gene in a Deciduous Forest Tree Alters Growth and Development and Leads to Stem Fasciation. Nilsson, O., Moritz, T., Sundberg, B., Sandberg, G., & Olsson, O. Plant Physiology, 112(2): 493–502. October 1996.
Expression of the Agrobacterium rhizogenes rolC Gene in a Deciduous Forest Tree Alters Growth and Development and Leads to Stem Fasciation [link]Paper   doi   link   bibtex   abstract  
  1993 (2)
Hormonal Characterization of Transgenic Tobacco Plants Expressing the rolC Gene of Agrobacterium rhizogenes TL-DNA. Nilsson, O., Moritz, T., Imbault, N., Sandberg, G., & Olsson, O. Plant Physiology, 102(2): 363–371. June 1993.
Hormonal Characterization of Transgenic Tobacco Plants Expressing the rolC Gene of Agrobacterium rhizogenes TL-DNA [link]Paper   doi   link   bibtex   abstract  
Separation and identification of cytokinins using combined capillary liquid chromatography/mass spectrometry. Imbault, N., Moritz, T., Nilsson, O., Chen, H., Bollmark, M., & Sandberg, G. Biological Mass Spectrometry, 22(3): 201–210. 1993. _eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1002/bms.1200220310
Separation and identification of cytokinins using combined capillary liquid chromatography/mass spectrometry [link]Paper   doi   link   bibtex   abstract  
{tab=Svenska} Thomas Moritz framför en masspektrometer

Min grupp studerar hur växthormoner och andra metaboliter reglerar tillväxt och utveckling i träd. Vi studerar framförallt hormonet gibberellin och dess roll i skottsträckning och vedbildning.

Vi har visat att genom att öka mängden gibberelliner i hybridasp så får man träd som i växthus uppvisar ökad höjd- och diametertillväxt. En upptäckt som kan få betydelse även ur ett prakiskt perspektiv.

I ett flertal projekt använder vi även metodik som kallas metabolomik för att kunna identifiera ämnen som är kopplade till trädets olika utvecklingsfaser. Fokus är framförallt mot hur olika metaboliter varierar i vedbildningszonen och deras function under vedbildningens olika faser.