UPSC Seminar Series 2014
Cutting Edge Seminar

Speaker:
Enrico Martinoia
University of Zurich Switzerland
Pohang University of Science and Technology, Pohang, Korea

Title: ABC transporters are major players in phytohormone transport

Place: Lilla hörsalen, KB3A9

Host: Urs Fischer

UPSC Seminar

Speaker:
Laurens Pauwels
VIB Ghent, Belgium

Title:
Dissecting the JAZ/TIFY protein interaction landscape

Host: Stephanie Robert
Room: Lilla hörsalen

UPSC Seminar Series 2014
Post-doc Seminar

Kerstin Richau
postdoc

Title:
Frankia & me:
An atypical relationship

Room KB3A9
Host AS

UPSC Seminar/CLiC/BILS seminar

Speaker:
John Marioni
EMBL-EBI/Wellcome Trust Sanger Institute/Single-Cell Genomics Centre (http://www.ebi.ac.uk/research/marioni

Title:
Computational challenges in single-cell transcriptomics – from immune cells to neurons

Room:
Lilla Hörsalen KB3A9

Abstract:

Recent technical developments, facilitated in large part by work at the Karolinska Institutet, have enabled the transcriptomes of hundreds of cells to be assayed in an unbiased manner. These approaches have enabled heterogeneity in gene expression levels across populations of cells to be characterized as well as facilitating the identification of new, and potentially physiologically relevant, sub-populations of cells.

However, to fully exploit such data and to answer these questions, it is necessary to develop robust computational methods that take account of both technical noise and underlying, potentially confounding, variables such as the cell cycle.

In this presentation I will begin by briefly describing how we used spike-ins to quantify technical noise in single-cell RNA-seq data, thus facilitating identification of genes with more variation in expression levels across cells than expected by chance. Subsequently, I will discuss a computational approach that uses latent variable models to account for potentially confounding factors such as the cell cycle before applying it to study the differentiation of Th2 cells. I will show that accounting for cell-to-cell correlations due to the cell cycle allows identification of otherwise obscured sub-populations of cells that correspond to different stages along the path to fully differentiated Th2 cells.

To conclude, I will discuss further applications of single-cell RNA-seq in the context of studying neuronal cell types, including olfactory neurons. I will also describe how we are studying heterogeneity in gene expression levels whilst taking into account the spatial location of cells from the tissue under study.

Welcome!

If you’re interested in meeting personally with John, contact Jeanette Tångrot and Nicolas Delhomme ( jeanette.tangrot at molbiol.umu.se and nicolas.delhomme at umu.se) as we have a few time slots available during the day.

Umeå Renewable Energy Meeting 2014 is planned to take place at Chemical Biological Centre.
The main organisers will be Thomas Wågberg, Ludvig Edman, department of Physics.

Date 17 - 19 March 2014

More about the annual meeting is found here:
http://www.kbc.umu.se/events/renewable-energy-meeting-2014.html

Umeå Renewable Energy Meeting 2014 is planned to take place at Chemical Biological Centre.
The main organisers will be Thomas Wågberg, Ludvig Edman, department of Physics.

Date 17 - 19 March 2014

More about the annual meeting is found here:
http://www.kbc.umu.se/events/renewable-energy-meeting-2014.html

Umeå Renewable Energy Meeting 2014 is planned to take place at Chemical Biological Centre.
The main organisers will be Thomas Wågberg, Ludvig Edman, department of Physics.

Date 17 - 19 March 2014

More about the annual meeting is found here:
http://www.kbc.umu.se/events/renewable-energy-meeting-2014.html

UPSC Cutting Edge Seminar 2014

Speaker:
Karin Schumacher
Plant Developmental Biology
Faculty of Biosciences, Ruprecht - Karls- University Heidelberg
Germany

Title:
Vacuoles - Pumping up the plant volume

Place: lilla hörsalen KB3A9
Host: Markus Grebe