August 2015
Tue. 25 Aug, 2015
Seminar - John O'Neill, MRC Laboratory of Molecular Biology, Cambridge
Tue. 25 Aug, 2015 10:00 - 11:00
UPSC Seminar
Speaker:
John O'Neill
MRC Laboratory of Molecular Biology
Cambridge University, UK
Title: Metabolic Oscillations in Yeast and Circatidal Cycles in Eurydice pulchra share - Features Conserved among Circadian Rhythms
Host. Maria Eriksson
Place: Lilla hörsalen, KB3A9, KBC
Abstract:
Circadian rhythms allow organisms to temporally orchestrate their internal state to anticipate and/or resonate with the external environment. Although 24-hr periodicity is observed across aerobic eukaryotes, the central mechanism has been hard to dissect because few simple models exist, and known clock proteins are not conserved across phylogenetic kingdoms. In contrast, contributions to timekeeping made by a handful of post-translational mechanisms, such as phosphorylation of clock proteins by casein kinase 1, appear conserved among phyla. These kinases have many other essential cellular functions and are better conserved in their contribution to timekeeping than any of the clock proteins they phosphorylate. Temperature compensation and metabolic rhythms are other universal features of circadian timekeeping. Here, we use comparative chronobiology to distinguish fundamental clock mechanisms from species-specific adaptations and thereby identify features shared between the mammalian cellular clock, ultradian respiratory oscillations in budding yeast and circatidal rhythms in the crustacean Eurydice pulchra. Our data point to common mechanisms underlying all three biological rhythms and suggest two interpretations: either certain biochemical systems are simply permissive for cellular oscillations (with frequencies from hours to days) or this commonality arose via divergence from an ancestral cellular clock.
Speaker:
John O'Neill
MRC Laboratory of Molecular Biology
Cambridge University, UK
Title: Metabolic Oscillations in Yeast and Circatidal Cycles in Eurydice pulchra share - Features Conserved among Circadian Rhythms
Host. Maria Eriksson
Place: Lilla hörsalen, KB3A9, KBC
Abstract:
Circadian rhythms allow organisms to temporally orchestrate their internal state to anticipate and/or resonate with the external environment. Although 24-hr periodicity is observed across aerobic eukaryotes, the central mechanism has been hard to dissect because few simple models exist, and known clock proteins are not conserved across phylogenetic kingdoms. In contrast, contributions to timekeeping made by a handful of post-translational mechanisms, such as phosphorylation of clock proteins by casein kinase 1, appear conserved among phyla. These kinases have many other essential cellular functions and are better conserved in their contribution to timekeeping than any of the clock proteins they phosphorylate. Temperature compensation and metabolic rhythms are other universal features of circadian timekeeping. Here, we use comparative chronobiology to distinguish fundamental clock mechanisms from species-specific adaptations and thereby identify features shared between the mammalian cellular clock, ultradian respiratory oscillations in budding yeast and circatidal rhythms in the crustacean Eurydice pulchra. Our data point to common mechanisms underlying all three biological rhythms and suggest two interpretations: either certain biochemical systems are simply permissive for cellular oscillations (with frequencies from hours to days) or this commonality arose via divergence from an ancestral cellular clock.
Mon. 31 Aug, 2015
WWSC Academy-UPSC Meeting, August 31st – September 2nd
Mon. 31 Aug, 2015 8:45 - 9:45
Thirty graduate students from the Wallenberg Wood Science Center Academy, accompanied by their coordinator Prof. Paul Gatenholm from Chalmers will be visiting UPSC during three days.
More information:
http://www.upsc.se/about-upsc/news/4758-wwsc-academy-upsc-meeting-august-31st-september-2nd.html
Registration form (deadline August 10)
More information:
http://www.upsc.se/about-upsc/news/4758-wwsc-academy-upsc-meeting-august-31st-september-2nd.html
Registration form (deadline August 10)