Mon. 11 Jun, 2012 - Sun. 17 Jun, 2012
Mon. 11 Jun, 2012
UPSC Half-Time Seminar: Malgorzata Pietrzykowska
Mon. 11 Jun, 2012 15:00 - 16:00
Speaker:
Malgorzata Pietrzykowska
Title:
Is there a functional difference between Lhcb1 and Lhcb2?
Place Lilla hörsalen
Tue. 12 Jun, 2012
Seminar - Beverley Green: Algal genomics and the evolution of light-harvesting antennae
Tue. 12 Jun, 2012 14:00 - 15:00
Department of Chemistry
Seminar
Beverley Green
University of British Columbia, Vancouver, Canada
Title: Algal genomics and the evolution of light-harvesting antennae
Host: Christiane Funk
Place: Lilla Hörsalen, KB3A9, KBC
Abstract:
The ocean is the new frontier in genomics research! The marine algae are particularly important because of their influence on global climate as well as their major contribution to the oceanic food web. The recently sequenced genomes of a number of these algae have illuminated the wide range of photosynthetic biodiversity in the ocean. Particularly interesting are the algae with chlorophyll a/c light-harvesting antennas, such as the diatoms and brown algae, which acquired their plastids by secondary endosymbiosis, and have derived new varieties of light-harvesting antennas.
Wed. 13 Jun, 2012
Cutting Edge Seminar - Theodorus Meuwissen: Prediction of total genetic value using whole genome sequence data
Wed. 13 Jun, 2012 10:00 - 11:00
Theodorus Meuwissen
Department of Animal and Aquacultural Sciences
The Norwegian University of Life Sciences (UMB), Ås, Norway
Title:
Prediction of total genetic value using whole genome sequence data
Place: Stora hörsalen, KBC
Fri. 15 Jun, 2012
Seminar - Kazuya Kikuchi: Design, synthesis and biological application of in vivo imaging probes with tunable chemical switches
Fri. 15 Jun, 2012 13:30 - 14:30
Seminar
professor Kazuya Kikuchi
Osaka University
Graduate School of Engineering
WPI-Immunology Frontier Research Center
Osaka, Japan
Title: Design, synthesis and biological application of in vivo imaging probes with tunable chemical switches
Host: Gunnar Öquist
Place: KBC, Large Lecture hall "Stora hörsalen"
Abstract:
One of the great challenges in the post-genome era is to clarify the biological significance of intracellular molecules directly in living cells. If we can image a molecule in action, it is possible to acquire biological information, which is unavailable if we deal with cell homogenates. One possible approach is to design and synthesize chemical probes that can convert biological information to chemical output. Protein fluorescent labeling provides an attractive approach to study the localization and function of proteins in living cells. Recently, a specific pair of a protein tag and its ligand has been utilized to visualize a protein of interest (POI). In this method, a POI is fused with a protein tag and the tag is labeled with the ligand connected to a fluorescent molecule. The advantage of this protein labeling system is that a variety of fluorescent molecules are potentially available as labeling reagents, and that the protein tag is conditionally labeled with its fluorescent ligand. I have designed a protein labeling system that allows fluorophores to be linked to POI. The protein tag (BL-tag) is a mutant class A ?-lactamase (TEM-1) modified to be covalently bound to the designed specific labeling probes and the labeling probes is consisted with a ?-lactam ring (ampicillin, cephalosporin) attached to various fluorophores. A fluorogenetic labeling system can be designed using the unique property of cephalosporin, which release leaving group by subsequent reaction after opening the lactam ring. For further sophisticated application, multicolor imaging was done by adopting the colorful fluorophores.
Seminar - Janne Lehtiö: Defining human proteome using high resolution peptide isoelectric focusing coupled to mass spectrometry (HiRIEF-LC-MS) and the application of this method to improve cancer treatment
Fri. 15 Jun, 2012 15:00 - 16:00
Seminar
Speaker:
Janne Lehtiö
Clinical Proteomics Mass Spectrometry, Karolinska Institutet, SciLifeLab Stockholm
Science for Life Laboratory
Title:
Defining human proteome using high resolution peptide isoelectric focusing coupled to mass spectrometry (HiRIEF-LC-MS) and the application of this method to improve cancer treatment
Place: Lilla hörsalen, KB3A9
Host Anders Nordström