Mon. 17 Oct, 2011 - Sun. 23 Oct, 2011
Tue. 18 Oct, 2011
Cutting Edge Seminar - Natasha Raikhel
Tue. 18 Oct, 2011 10:00 - 11:00
Title: Dissecting the Endomembrane Network via Chemical Genomics
Lecturer: Natasha Raikhel, University of California Riverside, USA
Place: KB3A9 "Lilla hörsalen", KBC
Abstract:
Although it is known that proteins are delivered to and recycled from the
plasma membrane (PM) via endosomes, the nature of the compartments and
pathways responsible for cargo and vesicle sorting and cellular signaling is
poorly understood. Such highly dynamic processes are not easily approached
genetically. To define and dissect specific recycling pathways, rapid-acting
chemical affecters of proteins involved in vesicle trafficking, especially
through endosomes, would be invaluable. Thus, we identified chemicals
affecting essential steps in PM/endosome trafficking by utilizing the
intensely localized PM transport at the tips of germinating tobacco pollen
tubes. We screened diverse chemical libraries for those that interfered with
pollen germination and tip growth. We found that many also had effects in
Arabidopsis roots for which there are several well-characterized marker
proteins that cycle to and from the plasma membrane. Recent results from our
screens will be discussed.
Lecturer: Natasha Raikhel, University of California Riverside, USA
Place: KB3A9 "Lilla hörsalen", KBC
Abstract:
Although it is known that proteins are delivered to and recycled from the
plasma membrane (PM) via endosomes, the nature of the compartments and
pathways responsible for cargo and vesicle sorting and cellular signaling is
poorly understood. Such highly dynamic processes are not easily approached
genetically. To define and dissect specific recycling pathways, rapid-acting
chemical affecters of proteins involved in vesicle trafficking, especially
through endosomes, would be invaluable. Thus, we identified chemicals
affecting essential steps in PM/endosome trafficking by utilizing the
intensely localized PM transport at the tips of germinating tobacco pollen
tubes. We screened diverse chemical libraries for those that interfered with
pollen germination and tip growth. We found that many also had effects in
Arabidopsis roots for which there are several well-characterized marker
proteins that cycle to and from the plasma membrane. Recent results from our
screens will be discussed.
Heather Knight - Dept. of Medical Biochemistry and Biophysics' Seminar Series
Tue. 18 Oct, 2011 15:15 - 16:15
Seminar
Heather Knight, School of Biological and Biomedical Sciences, Durham University, UK.
Title: SFR6, a key regulator of plant freezing tolerance and much more.
Place: KB3A9 kl 15.15
Host: Stefan Björklund - Dept. of Medical Biochemistry and Biophysics'
Heather Knight, School of Biological and Biomedical Sciences, Durham University, UK.
Title: SFR6, a key regulator of plant freezing tolerance and much more.
Place: KB3A9 kl 15.15
Host: Stefan Björklund - Dept. of Medical Biochemistry and Biophysics'